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KMID : 1007520150240041505
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Food Science and Biotechnology
2015 Volume.24 No. 4 p.1505 ~ p.1511
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Effect of Wild Korean Ginseng (Panax ginseng) Extract on Blood Glucose and Serum Lipid Contents in Rats with Multiple Low-dose Streptozotocin-induced Diabetes
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Moon Hye-Kyung
Kim Kil-Soo
Chung Shin-Kyo
Kim Jong-Kuk
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Abstract
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Anti-diabetic effects of wild Korean ginseng extracts on multiple low-dose streptozotocin (STZ)-induced diabetic rats were investigated. Rats were administered extracts at rates of 100, 200, and 300 mg/kg of body weight for 8 weeks. Body weight was significantly (p<0.05) lower in ginseng untreated diabetic rats than in ginseng treated rats in spite of significantly (p<0.05) higher food and water intake than for ginseng treated rats. Blood glucose levels were significantly (p<0.05) higher but plasma insulin levels were significantly (p<0.05) lower in 200 and 300 mg/kg of body weight ginseng treated diabetic rats than in rats treated with 100 mg of ginseng and in untreated control rats. The plasma aspartate aminotransaminase level was not significantly (p>0.05) affected; however alanine aminotransaminase and alkaline phosphatase levels were reduced significantly (p<0.05) in higher ginseng dosage rat groups. Anti-diabetic effects were elicited by administration of wild Korean ginseng extracts in multiple low-dose STZinduced diabetic rats.
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KEYWORD
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blood glucose, streptozotocin-induced diabetic rat, serum lipid, wild Korean ginseng
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